Sentence examples for binding to the major from inspiring English sources

The capability of DAPTA to potently block gp120 CD4 binding to the major co-receptor CCR5 explains its molecular and therapeutic mechanism of action as a selective antiviral entry inhibitor for R5 tropic HIV-1 isolates.

Structural superposition and subsequent mutagenesis experiments suggest that the basic protrusion motif plays a role in direct binding to the major groove in RNA/DNA hybrid, as well as in establishing the co-ordination among modules in RT necessary for proper function.

In our results, the second α-helix of the HTH contributes most of the DNA recognition, binding to the major grooves of the DR-DNA, and interacting mostly with the DNA bases.

On the other hand, an investigation of influences of carbon black nanoparticles on arylamine N-acetyltransferase [20] indicated that the NPs can change protein conformation and cause an irreversible binding to the major aromatic amine-metabolizing enzyme, thus leading to the loss of enzymatic acetylation activity toward carcinogenic aromatic amines.

In the search for an efficient method for rust cleaning, the focus has been both on a ligand showing strong complex formation with iron and weak binding to the major constituent ions in marble i.e. Ca II) and Mg II), as well as on the identification of a fast reducing agent able to reduce Fe(III) to Fe(II).

External binding to the major or minor DNA grooves can be responsible for the observed disturbance on DNA conformation [ 32, 33].

All NLSs bind to the major binding site, spanning armadillo repeats 1 4, and some also have a small additional contribution from the minor site, spanning repeats 6 8.[ 8] TPX2, however, binds primarily to the minor site of importin-α, thereby offering an opportunity for selectivity.

Powell contributed chapters on the binding to the two major works covering the book, the first being The Relics of St Cuthbert in 1956, a large work with chapters on Cuthbert's coffin and each of the objects recovered from it.

Earlier experiments in brain homogenates suggested a differential sodium regulation of ligand binding to the three major OR subtypes, in spite of their high degree of sequence similarity.

Interestingly, the recruitment of MOF was almost completely abolished in both MSL1- and MSL2-depleted cells, whereas the depletion of MOF had no effect on MSL1 and MSL2 binding to the Tsix major promoter and DXPas34.

Like the other vinca alkaloids, VRL and VFL exert their antitumour effect by binding to tubulin, the major component of microtubules in mitotic spindles.