Sentence examples for binding to the lid from inspiring English sources
Our observation that Rpn12 binding to the lid at a remote location can reposition the Rpn8-Rpn11 module suggests the possibility that ATP binding or hydrolysis by the base might also allosterically regulate this module through movements of the lid rather than direct contacts with the ATPase heterohexamer itself.
Altogether, the ensembles suggest that, upon initial substrate binding to the corresponding lid site, the opposing lid is maintained open and accessible for subsequent substrate binding.
Additional functions emerging for Int6/eIF3e include regulating protein turnover through its binding to the regulatory lid of the 26S proteasome [ 5] and the COP9 signalosome [ 6].
In contrast, ATP binding to the AMP-lid induces global domain closing, preventing further substrate binding to the ATP-lid site.
Additional contacts between Rpn12 and LP2 (and base) may also be necessary to promote an optimal conformation of the lid for binding to the base.
The 'switch' model suggests that ligand binding to the Popdc proteins will cause conformational changes such as movement of the lid domain over the PBC as has been proposed for other cAMP-binding proteins [ 36].
Given, for example, that the Cav3-binding site is localized to the lid region makes it likely that ligand binding will have an immediate impact on the Cav3 Popdc1 interaction.
Popdc1 was co-sedimented with Cav3 from membrane fractions, and the binding site for Cav3 is localized to the lid region of the Popeye domain.
This similarity also applied to the lid of Candida rugosa lipase in comparison to the potential lid of CALA.
The enlarged interaction interface of the inhibitors resulted in extension of small molecules binding toward the "lid" segment of MDM2 (residues 19 23)—a nascent element that interferes with p53 binding.
