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Well, according to Prof Sharp, it's because coffee is full of chemicals called polyphenols that are very efficient at binding to the iron and making that iron less soluble.
A multiple-site surface, such as the pyrite surface, offers the possibility to bind species that are chemically different; one species binding to the thiol surface group, the other binding to the iron surface group.
Conversely, DOX may also inhibit IRP [20], [22] preventing binding to the iron response element (IRE).
Hepcidin controls systemic iron fluxes by binding to the iron exporter ferroportin, inducing its internalization and degradation [ 12].
It is produced mainly in the liver and exerts its function by binding to the iron export protein, ferroportin, inducing its internalization and degradation [ 10].
Thus, after dioxygen binding to the iron centre an iron III)–superoxo complex is formed that reacts with αKG to form an iron(IV oxo and succinate.[ 24] In several nonheme iron enzymes, however, the iron III)–superoxo complex is known to abstract hydrogen atoms from substrates directly.
Similar(54)
The two-cysteine residues are reported to be involved for the binding to the iron-sulfur cluster in plant, P. aeruginosa and M. tuberculosis, which contribute to the difference in substrate specificity [ 58, 59].
Hepcidin acts as a gatekeeper for transmembrane iron transport [ 3], binding to the cellular iron efflux channel ferroportin, inducing its internalisation and degradation [ 4].
This includes the binding of diatomic ligands, especially the product, NO, whose binding to the heme iron blocks enzyme activity.
Comparison of the wild-type protein Mb and CuBMb shows that the copper ion in the distal pocket gives rise to significant effects on ligand binding to the heme iron.
These compounds were designed considering the anti-aromatase effect of some natural flavonoids and the importance of an azole ring for synthetic inhibitors such as letrozole or anastrozole towards binding to the heme iron of aromatase.
More suggestions(15)
binding to the p21
binding to the waaA
binding to the lipid
binding to the control
binding to the IFN-alpha
binding to the brain
binding to the a7-nAChR
binding to the membrane
binding to the promoter
binding to the soil
binding to the bottom
binding to the cmet
binding to the receptor
binding to the sugar
binding to the gold
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