Sentence examples for binding to the integrin from inspiring English sources

This region is adjacent to the actin-binding domain and is required for efficient binding to the integrin α6β4 in hemidesmosomes.

These compounds have been assayed for binding to the integrin receptors αIIbβ3 and αvβ3 and the results demonstrate the importance of the side-chain orientation of this particular residue within the RGD sequence.

In support of this hypothesis, N-PTB reduced PAC-1 antibody binding to the integrin receptor by 36%, whereas N-PTB4M decreased it by about 45% when analyzed by flow cytometry (Fig. 5B).

Inside-out activation begins with separation of the α and β tails and results in adoption of the extended-closed conformation [5], and is regulated by intracellular signals such as talin binding to the integrin cytoplasmic domain [6], [8].

In agreement with our model, N-PTB4M inhibited cell adhesion more efficiently (18.5%) (Fig. 5A), suggesting that abolishing sulfatide binding makes a larger pool of N-PTB available to compete with fibrinogen for binding to the integrin receptor.

Unexpectedly, the RGD peptide did not block the AGM binding to the integrin as analyzed by ELISA (data not shown).

For example, cyclic and linear derivatives of the oligopeptides RGD, through binding to the integrins α2β3, αvb3 and α5β1, can direct liposomes and other nanoparticles carrying vascular targeting and cytotoxic agents to endothelium and tumor cells, thus achieving significant antitumor activity (19– 219.

The observation that M3-protein binds to the integrin binding fragment of CIV suggests that it interferes with CIV-integrin interactions, modulates them or exploits them for the benefit of the bacterium.

Thus, the requirement of an active RGD sequence in BSP-mediated cancer cell invasion suggests that BSP binding to the αvβ3 integrin may promote clustering of integrin molecules, which could activate downstream signaling events.

In addition, FLNa binding to the β integrin tails blocks cell migration (4) and integrin activation [42], [43].

Furthermore the action of maspin on cell migration needed a 15-mer G-helix peptide right direct binding to the β1 integrin subunit resulting in the inactivation of β1 integrins (Figure 2) [9–11].