Sentence examples for binding to the histone from inspiring English sources

In addition to chromodomain binding to the histone tail, AT-Hook/ATHL can bind to the adjacent site in the minor groove of DNA, sandwiching the DNA between PC and histone surface (see Additional file 8).

Given that minimal alterations of the histone H3 tail peptide drastically reduce its affinity for PHD HD1 complexes, we surmised that we might be able to identify small molecules that bind to these histone pockets and interfere with their binding to the histone H3 tail.

TLE proteins can associate with condensed chromatin by binding to the histone tails of nucleosomes (Sekiya and Zaret 2007).

FIH is a protein hydroxylase that hydroxylates Asn803 of HIF and prevents it binding to the histone acetylase p300 (Schofield and Ratcliffe, 2005).

In turn, BCL9 adaptors use a separate domain (called HD1) to bind to the rear of the Pygo PHD fingers; they thus induce a subtle allosteric modulation of the PHD, which facilitates its binding to the histone H3 tail methylated at lysine 4 (H3K4me) through its frontal surface.

The majority of the coding variants identified in our cohort of breast cancer cases are situated in the forkhead-associated (FHA) domain and the two BRCT domains, and these domains have been demonstrated to be essential to NBN binding to the histone γ-H2AX [ 34, 35].

With differences between the WT and H4G94P interactions with Asf1, we assessed whether the mutation wouldprevent Asf1 from binding to the histones with a normal affinity.

Concerted binding to the methylated histone tail and nucleosomal DNA underlies the high- affinity, specific recognition of H3K36me nucleosomes by the PSIP1-PWWP domain.

We recently reported the discovery of several peptide ligands binding to the two histone demethylases KDM1A and KDM4C by phage display.

NMR and isothermal titration calorimetry (ITC) studies of H3/H4 binding to the yeast histone chaperone RTT106 found that H3 K56ac) significantly enhanced binding to a double pleckstrin-homology (PH) domain, while fluorescence studies found that H3 K56ac) increases H3/H4 binding to the yeast histone chaperone CAF-1.

Multiple histone chaperones have been implicated in the H3-K56 acycleation cycle, most notably Asf1p which binds one histone H3/H4 dimer and is absolutely required for H3-K56 acetylation by Rtt109p [48] [50] which in turn favors histone H3 binding to the Rtt106p and CAF1 histone chaperones [26].