Sentence examples for binding to the hinge from inspiring English sources

RNA does for example also play an important targeting function via its binding to the hinge region of the mammalian isoform of HP1a [15].

No localized conformational changes are observed with MW150 binding to the hinge region, such as the glycine flip observed with other promising p38αMAPK inhibitors.

A prototypical kinase inhibitor is generally an aromatic heterocycle that presents the classic H-bond donor/acceptor motif, which enables binding to the hinge region of the targeted kinase.

We synthesized an analogue of MELK-T1 named Compound 2 (Cpd2) (Janssen R&D; Figure 1A), in which the methylation of the amide disturbs the planarity of the N-phenyl benzamide and probably also the binding to the hinge region.

Importantly, RNA binding to the hinge region of Swi6 competes with methylated H3K9 for binding to the CD, predicting that Swi6 dynamics in vivo might be influenced by RNA (Keller et al, 2012).

Alternatively, association of Scc1 with cohesin could introduce a conformational change that allows Pds5 binding to the Smc hinge.

Together, these data show that pUb binding to the RING0/RING1 hinge interface results in a concomitant loss of structure near the C-terminus of helix H3 (RING1) and the IBR domain.

We have recently demonstrated that the ATP dependent engagement of Smc head domains together with DNA binding to the Smc hinge domain can transform the configuration of the Smc coiled coil from a rod to a more open ring-like conformation (Soh et al., 2015).

The result was a binding mode that shows a classic kinase inhibitor hydrogen bond donor/acceptor binding pattern to the hinge region.[ 20] Although good alignment was observed for the core motifs, the substituents occupy different areas of the binding site.

This experimentally confirmed binding mode to the hinge region of CHK2 through a conserved water molecule has previously been observed for NSC109555, but has not previously been seen for a benzimidazole scaffold, and may provide a useful approach to selective small molecule inhibitor design for CHK2.

The sphere set used as matching points for docking was manually generated by placing matching atoms into the adenine binding region close to the hinge region.