Sentence examples for binding to the high from inspiring English sources
This implies some restriction of diffusion and possibly binding to the high surface area of the outer biofilm.
Using sodium hypochlorite, a powerful oxidant produced by the H2O2-myeloperoxidase-Cl system, we now demonstrate that binding to the high affinity sites correlates directly with activation of the signaling cascade.
Direct binding studies with K1374R demonstrated no significant alteration in binding to the lower affinity site; however, binding to the high affinity site is reduced by 83%.
Mutation of Lys-1370 to Ala resulted in a 4-5-fold increase in the Kd for binding to the lower affinity site with no significant alteration in binding to the high affinity site or signal transduction properties.
Finally, the mature form is internalized by the postsynaptic membrane through binding to the high affinity TrKA (tropomyosin-related kinases) receptor (for a review see [ 20]).
IL-2 might be rapidly consumed through binding to the high avidity CD25 receptor expressed by regulatory T cells and by effector memory T cells upon activation.
Heparan sulfate proteoglycans have been shown to play an obligate role in basic FGF binding to the high-affinity FLG receptor.
The conditions of the titration pairs, A/B and C/D, were selected to yield affinities and stoichiometries, respectively, of PAPS binding to the high-affinity (A/B) and low-affinity (C/D) sites of the enzyme.
As well as directly inhibiting the channel, sulphonylurea binding to the high-affinity site also suppresses the activatory effect of MgADP (or MgATP); this in turn 'unmasks' the inhibitory effect of the nt which is then combined with that of the sulphonylurea.
kon and koff for binding to the high-affinity site were obtained by rapidly mixing [1 1 (v:v)] a solution containing SULT1A1 (30 nM, dimer), MgCl2 (5.0 mM), and NaPO4 (25 mM) at pH 7.2 and 25 ± 2 °C with a solution that was identical except that it contained PAPS and was without enzyme.
