Sentence examples for binding to the heme from inspiring English sources
We describe the structural requirements for optimum (i) binding to the heme periphery and (ii) inhibition capacity.
This includes the binding of diatomic ligands, especially the product, NO, whose binding to the heme iron blocks enzyme activity.
Comparison of the wild-type protein Mb and CuBMb shows that the copper ion in the distal pocket gives rise to significant effects on ligand binding to the heme iron.
These compounds were designed considering the anti-aromatase effect of some natural flavonoids and the importance of an azole ring for synthetic inhibitors such as letrozole or anastrozole towards binding to the heme iron of aromatase.
The invariance of these residues for all the sequences available during the 1970s thus could plausibly be attributed to their crucial role in binding to the heme via their distinctive side chains.
The mechanism of action of azole antifungals relies on their ability to inhibit synthesis of sterols in fungi via inhibiting cytochrome P450-dependent 14α-lanosterol demethylase through binding to the heme cofactor of the cytochrome CYP51 [11] 11]. Figure 1 Chemical structures of common antifungal azole drugs.
It has been proposed that hxHbs might destroy NO through a mechanism that includes binding to the ferric heme iron [38].
Physiologically, nitric oxide, carbon monoxide and superoxide bind to the heme-binding site of enzymes of the CYP4A pathway and inhibit the formation of 20-HETE [ 1].
Heme also controls target gene translation by binding to the two heme-binding domains of HRI, a known protein kinase [ 50].
It was suggested that this amino acid regulates the migration of small ligands in rice Hb1, for example in ligand binding to the Fe-heme, ligand migration through internal docking sites and ligand release into the external solvent.
However, in rice Hb1 and 2, and possibly in rice Hb3 and 4, the bound O 2 is stabilized by distal His after binding to the Fe-heme, which results in very low O 2-dissociation rate constants.
