Sentence examples for binding to the fat from inspiring English sources

The resulting new compounds were evaluated for their binding to the FAT domain of FAK and anti-cancer activity.

Amongst all tested analogs, compound 29 augmented anti-proliferative activity in multiple cancer cell lines with stronger binding to the FAT domain of FAK and disrupted the FAK VEGFR3 interaction.

DEPTOR appears to play a key role in mTOR signaling and directly inhibits mTOR activity by binding to the FAT domain.

Back to The Fat of the Land.

In addition, NAMPT was shown to be produced by visceral fat as a secreted adipokine called visfatin that exhibited insulin mimetic functions through binding to the insulin receptor[6].

However, it is still possible that the F domain's effects are mediated by Fbxl7, especially since Fbxl7 has residual binding to Fat lacking the D domain.

Rosiglitazone acts as an insulin sensitizer, binding to receptors in fat cells that render the cells more responsive to insulin [ 43].

Previous experiments performed on cells grown in the laboratory showed that when Four-jointed adds phosphate groups to Fat and Dachsous, it prevents Dachsous from binding to Fat.

The potential contribution to the H3T assay signal by non-specific Ab6 and B9A11 binding to fat and non-tumor stroma was evaluated by comparing H3T measurements obtained using multiple paired tumor sections that were or were not macro-dissected to remove non-tumor tissue prior to testing.

The more lipophilic molecule is undesirable not only for slowing passive brain entry but also for increasing high non-specific binding to brain fats and protein.

The FKBP12-rapamycin binding domain (FRB) is adjacent to the FAT domain and is the site of interaction between mTOR and FKBP12 protein bound to rapamycin [ 11].