Sentence examples for binding to the enhancer from inspiring English sources
We showed previously that AcP10 loops to Myc, and that the risk allele of rs6983267 enhances TCF7L2 binding to the enhancer (Pomerantz et al., 2009a).
PARP-1 PARylates Sox2 during ES cell differentiation inhibits Sox2 binding to the enhancer region of fibroblast growth factor 4 (FGF4), leading to enhanced FGF4 expression, and promoting differentiation.
Enhancer repression following hormone treatment seems independent of receptor motifs and receptor binding to the enhancer, as we show using ChIP-seq, but appears to rely on motifs for other factors, including Eip74.
To confirm that this periodicity is not particular to DFO, we investigated the kinetics of p300 binding to the enhancer in cells cultured under hypoxia, using a time course with prolonged intervals between each time point.
The greater nucleosome density in the absence of TSA is seen in the regions flanking the vgQ enhancer, but not in the vgQ enhancer itself, possibly because sequence specific factors binding to the enhancer disrupt nucleosome assembly.
The AP-1 transcription factors, originally identified by their binding to the enhancer element of the simian virus 40 (SV40) promoter [10], function as homo- or heterodimers composed of members of the jun, fos and atf multigene families [11].
Interestingly, in mES cells p53 is able to regulate gene transcription through binding to the enhancers far from the gene body [ 59].
TNFα induction of NF-κB binding to the distal enhancer recruits the histone acetyl transferase p300/CREB binding protein, which acetylates the distal enhancer- and proximal promoter-associated histones.
Further, SUMO-1-conjugated Sox2 at the lysine 247 or at the carboxyl terminus reduced the binding to the Fgf4 enhancer.
The second key segment of the NF-kB activation pathway is nuclear translocation of NF-kB subunits and their dimerization and binding to the kB enhancer.
Knockdown of NCYM diminished MYCN binding to the distal enhancer of OCT4 (Fig. 2e).
