Sentence examples for binding to the endogenous from inspiring English sources

By binding to the endogenous site, Zn2+ acts as a potent non-competitive inhibitor of dopamine uptake mediated by the hDAT transiently expressed in COS-7 cells.

As shown in Fig. 4, there was marked enrichment of palladin binding to the endogenous SMA promoter region in both A404 and R518 cells (p<0.05).

Moreover, no binding of these two proteins in the Xenopus haemoglobin promoter which lacks Pax2 and Sox2 binding sites was detected, confirming the specificity of Pax2 and Sox2 binding to the endogenous Xenopus HCNR 81675 (Figure 6B and quantitative PCR results shown in Figure 6C).

This was tested by luciferase reporter assays in the AR-negative cell line to avoid binding to the endogenous protein.

By presenting the antigen in its native conformation for immunisation and hybridoma selection, this procedure promotes the generation of antibodies capable of binding to the endogenous protein.

Furthermore, antibodies generated against a purified recombinant protein are frequently incapable of binding to the endogenous protein in its native context.

To our surprise, however, pS3291-BRCA2 was barely detectable in the Rad51 immunocomplexes from the soluble fraction, suggesting that an as-yet-unknown mechanism may interfere with Rad51 binding to the pool of endogenous BRCA2 that is physiologically phosphorylated at S3291, despite the presence of additional Rad51-binding BRC motifs in the middle region.

The study results suggest that after P140 peptide binding to HSC70, the endogenous (auto antigen processing might be greatly affected in MRL/lpr antigen-presenting B cells, leading to the observed decrease of autoreactive T-cell priming and signalling via a mechanism involving a lysosomal degradation pathway.

Chromatin IP has confirmed Smad4 binding to the SBE region in the endogenous LAMA3 promoter [ 19].

This probe has capacity of tightly binding to the APN for imaging endogenous APN in living human ovarian clear cell carcinoma cells (ES-2) and has potential application in biological study of cellular APN.

Myc binding to miRNA loci occurred to the same extent as endogenous binding to the Myc target gene HirA (Chen et al, 2008; Kim et al, 2008).