Sentence examples for binding to the dopamine from inspiring English sources
Both epileptic groups presented elevated binding to the dopamine transporter and low tissue content of dopamine and its metabolites.
Furthermore, using previously published data, a 3D-QSAR model was developed for cocaine binding to the dopamine reuptake transporter (DAT) that was compared to the mAb models.
The search for a functional antagonist to the addictive properties of cocaine has focused on the discovery of a molecule that can inhibit cocaine binding to the dopamine transporter (DAT) but continue to allow dopamine transport by the DAT.
Specifically, BNO 1095 extract preparations demonstrated specific binding to the dopamine D2 receptor [27, 28], which would thereby inhibit prolactin release from the pituitary gland and down-regulate a systemic hormonal cascade ultimately responsible for a wide range of menstrual symptoms in women suffering from PMS.
The mice also display a selective facilitation of long-term potentiation (LTP) in the medial perforant path and a selective enhancement in rapid-acquisition spatial memory, phenotypes that are reversed by direct application of a cell-permeant peptide (DNIP) designed to interfere with NCS-1 binding to the dopamine type-2 receptor (D2R).
In SPECT and PET imaging studies, radioligand binding to the dopamine receptor or transporter reflects the occupancy by dopamine itself or antipsychotics.
When the VAC extract BNO 1095 was added instead of the non labeled dopamine this resulted also in a dose dependent displacement of the labeled dopamine (Fig. 4) indicating binding to the recombinant dopamine receptor and thereby displacing the radioactively labeled dopamine from the receptor.
The present in vitro study investigates the effects of X-ray on the irreversible binding to the striatal dopamine transporter (SDT) using three different photoreactive affinity ligands, RTI-38, RTI-63, and RTI-78.
In addition to tiapride binding to the supersensitive D2 dopamine receptors in the ventral striatum and parts of the limbic system (Locus coeruleus), a blockade of some serotonergic receptors (5HT3, 5HT4) is assumed.
In contrast, the Ala248Val mutation enhanced agonist-induced arrestin-3 binding to the β2-adrenergic and D2 dopamine receptors, while reducing its interaction with the D1 dopamine receptor.
The genuine strength of this powerful molecular imaging modality is its picomolar sensitivity and the possibility of quantitative imaging of in vivo binding to the specific neuroreceptors like TSPO, dopamine receptors and serotonin receptors.
