Sentence examples for binding to the conserved from inspiring English sources
Moreover, the residues near His-23 and -159 do not exhibit ligand-induced chemical shift perturbations at pH 7.4, suggesting that these sites and the pocket are structurally independent and pH-dependent structural changes at these sites do not affect ligand binding to the conserved pocket.
We therefore speculate that the positively charged surface of kurtoxin is an important determinant of its binding to the conserved negative domain in Cav3 (T-type) Ca2+ channels.
While most of the functional studies of WRKY proteins indicate a binding to the conserved nucleotide consensus sequence TGAC(C/T) of the W-box, the binding to another cis-element called SURE has also been described [ 15].
Through this effort we provide the first comprehensive structural analysis of ligand binding to the conserved pocket of RKIP in solution.
The compound library contained compounds presumed to have an increased probability of binding to the conserved ATP-binding pocket of protein kinases.
Therefore, the absence of these proteins would result in decreased activation due to less binding to the conserved cis-acting UAS INO element contained in their promoters.
We then tested the hypothesis that antisense molecules, i.e. short peptide nucleic acids (PNA), could inhibit HCV translation by binding to the highly conserved IIId or IV loop regions of the IRES.
Rapamycin and FK506 are structural analogues that compete for binding to the highly conserved FK binding protein-12 (FKBP-12).
The HD is responsible for the specific binding to DNA and the Zip domain acts as a dimerization motif; dimerization is a prerequisite for binding to the phylogenetically conserved target sequence CAAT (A/T) ATTG [ 14, 15].
A well-described inhibition mechanism of NF- κB by electrophiles occurs through covalent binding to the highly conserved cysteines at position Cys-38 of p65 and Cys-62 of p50, within their DNA-binding domain.
Putative aromatic residues of binding to the carbohydrate substrates were conserved in three-fourths of aromatic residues between ManF-X10 and Man26E.
