Sentence examples for binding to the channel from inspiring English sources

Molecular dynamics (MD) simulations are used to determine the bound configuration of the [Lys]-fullerene and calculate the potential of mean force (PMF) of the [Lys]-fullerene binding to the channel.

If PBA is directly binding to the channel, the slowed kinetics could be explained by a cytoplasmic or buried binding site.

The burst of Ca2+ into the cytoplasm of STIM2-ORAI1 cells after STIM-independent ORAI1 induction attributable to 2-APB binding to the channel was described by Putney's group [34].

Using this assay, we observed that both prokaryotic and eukaryotic Kir channels are indeed enantioselective for cholesterol, indicating that modulation by this sterol is mediated by direct binding to the channel.

To characterize further the effect of the T63S mutation on ion binding to the channel, we employed a biochemical assay [15] in which the effects of potassium and barium ions on the stability of the channel tetramer was examined (Figure 6).

Progesterone was the strongest inhibitor, and, like dihydrotestosterone, had a rapid and reversible effect in excised membrane patches, suggesting the possibility of direct steroid binding to the channel.

10 Memantine is a fast-binding antagonist which binds to the channel in a pseudo-first order manner.

CAD is a small 107 aa polypeptide that activates Ca2+ release-activated Ca2+ (CRAC) channels by binding to the CRAC channel protein Orai1 [16].

These patients are comparatively insensitive to Class III IKr/HERG blocking drugs [27,61] and the N588K HERG blocking potencies of the IKr/HERG blockers E-4031and D-sotalol areducedced ∼12 20-fold ∼12 20-fold their effecomparedtoHERG [62,63], presumably due theirroleffectsct on otherWT HERGf channel inactivation in facilitating drug binding to the HERG channel.

Therefore, it seems likely that Gαi1(GDP) turns off GIRK by simply binding to the free (channel unbound) form of Gβγ and shifting the equilibrium away from channel occupancy by Gβγ.

By physically binding to the GIRK channel, RGS7/Gβ5 may further act to promote productive interactions of Gβγ (and/or Gα) with the channel, thus increasing cooperativity of its activation.