Sentence examples for binding to the central from inspiring English sources
Additionally, clonazepam promotes brain stem serotonergic descending pain inhibition by binding to the central GABAA receptors located within the brainstem [29].
LNZ inhibits the formation of protein synthesis initiation complexes by binding to the central loop segment of domain V of the 23S rRNA [ 6].
Inhibition of hIK1 and Kv1.1 potassium channels by polyunsaturated fatty acids has also been attributed to binding to the central cavity.
Instead, it is proposed that the EPR studies detect binding to the central hydrophobic cavity of the channel, with a binding constant in the range of ∼0.1 1 μM.
Therefore, the interaction between RILP and RalGDS may not affect the interaction of RalGDS with Ras/Ral, but interfere with the GDP/GTP exchange activity of RalGDS due to the binding to the central CDC25 region.
As shown in Figure 3A, incubation of KcsA with TBA results in a decreased fluorescence emission at low wavelengths, where the spectra are dominated by the KcsA-bound component, with no effects at higher wavelengths; the effects of TBA increase with increasing concentration as expected for simple competition between Dauda and TBA for binding to the central cavity in KcsA.
The midbody itself represents the last connection between the dividing cells, and KIF14 had been detected in this structure as well (Carleton et al, 2006; Gruneberg et al, 2006), possibly as a consequence of a persistent binding to the overlapping central microtubules.
After binding to the peripheral neurons, the central domain of BoNT helps the LC translocate into cytosol where its proteolytic action on SNARE (soluble NSF attachment protein receptor) proteins blocks exocytosis of acetyl choline leading to muscle paralysis and eventual death.
The linings of the central pores of pentameric ligand-gated ion channels have also been shown to be hydrophobic; blockage of these channels by quaternary ammonium ions and by hydrophobic, positively charged drugs such as lidocaine again follows from binding to the hydrophobic surface of the central pore.
Black dashed lines indicate access pathways from the periplasmic space into the drug-binding sites, in the L and T states, and from the binding site to the central funnel (green dashed line) within the funnel domain, in the O state.
Most of Spain's 17 regions are requesting changes to the legal ties binding them to the central government in Madrid.
