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Methadone, typically taken by mouth in liquid form, blocks addicts' cravings for heroin by binding to the brain's opioid receptors.
In mice, toxin binding to the brain is inhibited by prior administration of the inactive prototoxin [7], [18].
TNFα can increase platelet binding to the brain microvasculature in ECM [9], further demonstrating this important interplay between platelets and immune responses in cerebral malaria.
Radioactivity (i.e. GTPγS binding to the brain extracts) was measured using MultiLex melt on scintillator sheets (Perkin Elmer) in a liquid scintillation counter (1450 Microbeta Plus; Wallac).
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A-844606 displaced [3H]MLA binding to the rat brain membrane with an IC50 value of 11 nM [27].
In our assay, the IC50 values of SSR180711 and CHIBA-1001 for [125I]α-bungarotoxin (0.5 nM) binding to the rat brain homogenates were 24.9 and 45.8 nM, respectively.
Most recently, the F.D.A. approved Chantix, which works by binding to the nicotine receptors in the brain.
But some companies have developed patented compounds that mimic melatonin by binding to the same receptors in the brain as the hormone.
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Somatostatin analogues, which can be defined as peptide receptor radionuclide therapeutic agents, are the only approved cancer therapeutic peptides in the market [ 249] and there are reports of their binding to the cellular receptors in brain tumors in vivo [ 250].
Urocortin 1-3 interact with the corticotrophin system in the brain by binding to the same receptors and can alter stress and anxiety [ 80- 83].
More suggestions(16)
binding to the majority
binding to the glucocorticoid
binding to the region
binding to the zona
binding to the aryl
binding to the adaptor
binding to the yeast
binding to the end
binding to the mitochondria
binding to the dimer
binding to the integrin
binding to the host
binding to the zinc
binding to the origin
binding to the androgen
binding to the peptide
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