Sentence examples for binding to the adaptor from inspiring English sources
One mechanism by which intracellular protein complexes and organelles are tagged for delivery to autophagosomes is through binding to the adaptor protein, p62, which recognizes polyubiquitinated targets and also bind to LC3 through its LC3-interaction region (LIR).
In contrast, the PYD-containing NLRP proteins (formerly named Nalps) drive caspase-activation by binding to the adaptor protein ASC leading to the processing of pro-inflammatory cytokines [15], [16].
In contrast, several PYRIN domain containing Nalp proteins were found to form a signaling platform, dubbed inflammasome, and drive caspase-activation by binding to the adaptor protein ASC [1], [7], [12], [13].
Co-immunoprecipitation revealed that EGF increases MEKK2 binding to the adaptor protein Lad1, and this interaction was reduced by the intracellular calcium modifiers, indicating that a proper calcium concentration is required for the interactions and transmission of EGF signals to ERK5.
All have similar structure with domains for binding to the adaptor protein PIK3R1 (p85) and to RAS (Fig. 3a).
In summary, the main function of Opy2 is to serve as a membrane anchor for the Ste11 MAPKKK through its binding to the adaptor protein Ste50.
In this sense, we proposed that binding to the adaptors Gab1, Gab2 and Vav could localize YopH at sites where signalling complexes are formed.
Remarkably, all six XLP2-BIR2 mutabrogatedrogathe the co-purification of endogenous RIPK2 with XIAP, whereas the binding to the TAK1 adaptor protein TAB1, which binds to the XIAP BIR1 domain, was unaffected by the mutations [ Fig 4B; (Lu et al, 2007)].
In this way, CUL3 acts as an active scaffold to direct ubiquitylation, as C-terminally bound RBX1 binds ubiquitin-conjugating E2 enzymes that are charged with ubiquitin, while simultaneously binding to the substrate adaptor, in this instance KLHL3.
PAG also restricts the mobility of lipid rafts within the membrane via its binding to the cytoskeletal adaptor EBP-50 [ 16, 17].
Src-mediated phosphorylation of p130Cas/BCAR1 at specific tyrosine residues is responsible for Cas binding to the Cul5 adaptor SOCS6 and its consequent ubiquitylation by Cul5.
