Sentence examples for binding to the activated from inspiring English sources

Smad7 competes with both Smad2 and Smad3 for binding to the activated TGFBR1 and prevents their activation and propagation of the signal into the nucleus [ 8].

Using an antibody that specifically recognizes an epitope overlapping the nuclear localization signal of the p65 subunit and, thus, selectively binding to the activated form of p65 (indicated as p65*), we evaluated the activation of NF-κB in single and double transgenic mice at the onset stage by Western blot.

Together with the Western blot data showing a reduction in PLC- γ1 tyrosine phosphorylation, we conclude that the PS2-TAT protein most likely competes with the native PLC -γ1 protein for binding to the activated EGFR/c-erbB-2 heterodimer, thereby inhibiting PLC -γ1 activation.

Platelet activation was measured by surface expression of P-selectin and PAC-1 binding to the activated conformation of the GPIIb/IIIa receptor (GPIIb/IIIa-act).

Thus, the slow rate of receptor internalization cannot be due to impairment in β-arrestin-2 binding to the activated receptor.

This molecule has been thought to inhibit signaling by competing with endogenous FADD protein for binding to the activated death receptors.

In contrast, a chimeric murine IgG2a variant of 3/23 displaying strong binding to the murine activating Fc γ receptors but only poor binding to Fc γRII showed no or only marginal immune stimulatory activities.

In summary, the demethylation of NR2B gene promoter might increased CREB binding to the promoter and activated transcriptional activity of the NR2B gene.

What is currently unclear is whether ethylene binding to the receptors activates or inhibits their His kinase activity, in vitro analysis suggesting inhibition but genetic analysis suggesting activation (Voet-van-Vormizeele and Groth 2008; Hall et al. 2012).

Ligand binding to the EGFR activates cell signaling.

How a protein binding to the extracellular region activates the intracellular kinase domain has been the subject of over two decades of research (Lemmon and Schlessinger, 2010).