Sentence examples for binding to target sites from inspiring English sources

Increasing primer concentration in this dimer-forming multiplex appears to diminish overall product yield, as more primers accelerate dimer formation, which then outcompetes binding to target sites.

Biosensor-surface plasmon resonance methods were used to monitor HMGA2 binding to target sites on immobilized DNA, and a competition assay for inhibition of the HMGA2 DNA complex was designed.

Some different action modes were also reported in a few mRNAs, including transcriptionally inducing or silencing gene expression through binding to target sites in the promoter region of a gene [16], [17].

MicroRNAs (miRNAs) are an abundant class of ∼22 nt long endogenous non-protein-coding RNAs that function by binding to target sites on 3'-UTRs of messenger RNAs (mRNAs) to repress translation or mediate mRNA degradation (reviewed in [1]).

This suggests that STAT3 binding to target sites is not sufficient in inducing gene expression, and tissue-specific transcription factors, or trans-activators that specifying modification in the chromatin region may also be required [59], [60], [61], [62].

The observation that p63 and p73 directly associate with the same set of genomic targets suggests that their distinct biological functions are due to cell-type specific expression and/or protein domains that involve functions other than intrinsic or cooperative DNA binding to target sites.

Structure features are derived from DNA three-dimensional structures, which play important roles in guiding DNA-binding proteins to target sites efficiently [ 15, 16].

miRNAs act as gene regulators through translational repression or mRNA degradation via binding of miRNAs to target sites in the 3'-untranslated regions (UTR) of protein-coding transcripts.

Nucleosome organization governs the accessibility of chromatin to regulatory complexes, increasing the binding of nonhistone proteins to target sites.

The third PHD domain in MLL1 is important for H3K4me3 binding and MLL1 recruitment to target sites in the Hox locus 34.

These data suggest that the presence of mt p53 inhibits the binding of wt p53 to its targets, and possibly allows for binding to non-target sites.