Sentence examples for binding to target sequence from inspiring English sources

It indicated that SOX10 (SRY-related HMG-box 10, SRY for sex determining region Y) was the most possible TF binding to target sequence (Table 5).

Astriab-Fisher, A; Sergueev, D; Fisher, M; Shaw, BR; Juliano, RL, "Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions"., Pharm Res, 2002, 19 6), 744-754 [Gateway.cgi], [doi] [abs].

The same study also showed preferential binding to target sequences containing a mismatch.

miRNAs (20 22 nt long) are know factors that suppress expression of many genes by binding to target sequences in the 3'UTR of many mRNAs.

Primers and probes used in the RT-PCT were as follows: MS2-F and MS2-R: Forward and reverse primers binding to target sequences on the internal MS2 bacteriophage control, 20 pmol/µl each.

The results shown here suggest that the in vitro DNA binding specificity of CbfA translates to the in vivo situation in that CbfA binding to target sequences occurs at the AT-hook of the CbfA-CTD, is DNA sequence-specific, and apparently occurs only a very small and distinct number of genomic loci.

5' Rox- CAC ATC GAT AGA TCA AGG TGC CTA CAA GC BHQ2 3' AM-F and AM-R: Generic forward and reverse primers respectively binding to target sequences in the Influenza A matrix gene, enabling amplification of the matrix RNA as a marker of virus genome copies 20 pmol/µl each.

Of particular interest are a class of small RNAs, the microRNAs (miRNAs), which act as regulators of gene expression by binding to target sequences within the 3′ untranslated regions of mRNAs to modulate transcript stability and translation efficiency (31).

Primers were designed using web-based tools, Primer3 http://frodo.wi.mit.edu/primer3/ or Universal Probe Library (Roche Inc., Indianapolis, IN) and verified by BLAST searches to confirm their specific binding to target sequences (Table 3).

miRNAs are small noncoding RNAs of 21 25 nt, which usually negatively modulate gene expression at the posttranscriptional level by incomplete or complete complementary binding to target sequences within the 3′ untranslated region (UTR) of miRNA [ 6].

Unpublished data from our laboratories, however, suggest that in some cases (e.g., in Ewing's sarcoma) the inhibition of transcription factor binding to target sequences does not last very long, and transcription modulation occurs for a short time, possibly not sufficient to exert a significant anti-tumour effect.