Sentence examples for binding to target proteins from inspiring English sources
IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins.
We propose a novel method for virtual ligand screening to explore drug candidates binding to target proteins.
O-GlcNAc modification of HSP70 might mediate cellular protection by its binding to target proteins [49].
SH3 domains contribute not only to SFK regulation (see Introduction) but also to substrate recruitment by binding to target proteins containing polyproline type II helices [23].
Short p53 TAD fragments in the intrinsically disordered p53-NTD domain were able to form 'induced helices' upon binding to target proteins [8], [40].
Such changes affect binding to αB-crystallin and heterooligomerization [21] and also seem to affect binding to target proteins decreasing the chaperone activity.
The ability to confirm the primary on-bead hits by measuring their binding to target protein in homogenous solution is essential for an efficient use of one-bead one-compound (OBOC) library screening.
The pharmacological response of SFN and related isothiocyanates is associated with reversible binding to target protein thiols (protein thiocarbamoylation) which increases over the initial 4 h, remaining above the half-maximal value for 6 8 h and declining thereafter; cf. reversible cell protein binding by phenethyl isothiocyanate (64).
Thus, we can conclude that the binding affinity to target proteins does not always concur with the chaperone activity data.
However, nonnative hydrophobic interactions can also hamper specific binding of IDPs to target proteins because of kinetic traps.
