Sentence examples for binding to target mRNA from inspiring English sources

MiRNAs post-transcriptionally regulate gene expression by binding to target mRNA to suppress its translation or regulate its degradation.

MicroRNAs (miRNAs), a group of small (19 25 nucleotides) non-coding segments of RNA, regulate gene expression by binding to target mRNA to inhibit their translation.

It has been suggested that the presence of single nucleotide polymorphisms in precursor miRNAs (pre-miRNAs) can alter miRNA processing, expression, and/or binding to target mRNA and represent another type of genetic variability that can contribute to the susceptibility of human cancers.

MiRNAs are generally imperfectly complementary to the 3' UTR of the target mRNA, with only 2 7 nt at the 5' end being perfectly complementary and forms a bulge upon binding to target mRNA [31], [32].

MicroRNAs (miRNAs) are small (19 25 nucleotides) noncoding segments of RNA that regulate gene expression by binding to target mRNA and inhibiting their translation [ 7– 9].

Mature miRNAs harbor a two to eight nucleotide 'seed' region at the 5' end of the miRNA that is crucial for binding to target mRNA.

MicroRNAs (miRNAs) are small endogenous RNAs of approximately 23 nucleotides that regulate the cellular transcriptome by binding to target mRNAs in a sequence-restricted manner, thereby modulating target transcript translation and turnover.

MicroRNAs are a class of small non-coding RNAs that have emerged as key regulators of gene expression at the post-transcriptional level by sequence-specific binding to target mRNAs.

Such functional roles are likely influenced by subcellular distribution, which controls binding to target mRNAs or other compartment-specific functions.

They modulate gene expression by complementarity-mediated binding to target mRNAs resulting in the repression of translation [11] or in the cleavage of the target transcript [12], [13].

Thus, we provide novel evidence that the tumor suppressor function of pp32 can be attributed to its ability to disrupt HuR binding to target mRNAs encoding key proteins for cancer cell survival and drug efficacy.