Sentence examples for binding to target gene from inspiring English sources
Given a finite number of transcription factor molecules available inside a nucleus [11], an inevitable outcome of their binding to target gene enhancers is an enrichment of these molecules at the locations of their target genes [23].
Furthermore, temperature-dependent phosphorylation of CCA1 modulates its binding to target gene promoters [ 24].
Such a mechanism implies that YAP binding to target gene promoters would be regulated by miR-130a.
It has been shown that p53H175 exerts a dominant-negative effect on wtp53, preventing wtp53 binding to target gene promoters.
These results could be explained by a lack of c-Myb binding to target gene promoters in estrogen-deprived cells.
p53 functions as a crucial transcription factor in a well established response through direct protein binding to target gene promoter elements.
In embryonic stem cells (ESCs), inactivation of SMARCA4 leads to defective self-renewal and promotes differentiation, while overexpression enhances the epigenetic reprogramming of fibroblasts into induced pluripotent stem (iPS) cells, possibly through increased OCT4 binding to target genes (Singhal et al., 2010).
Rabbit antibody specific for RIZ1 but not RIZ2 from Abcam (ab9710) was used for ChIP analysis of RIZ1 binding to target genes.
Many of the conclusions reached to date regarding the Myc target gene networks rely on gene expression changes coupled with Myc binding to target genes as determined by chromatin immunoprecipitation (ChIP [7], [8].
Hence, the identification of direct target genes for any transcription factor performed to date is limited by assuming that transcription factor binding to target genes results in their altered transcriptional rates.
