As in the case of S. mutans, binding sub-fraction #5 to surface proteins of P. intermedia may result in denaturation and inactivation of their physiological functions.
Moreover, Ssu05_1371 was highly similar to other streptococcal proteins that have characteristic functions attributed to surface proteins, as binding to the extracellular matrix (ECM) of the host cells (Additional File 3).
In contrast to NaD1 PIP2 oligomers, these fibril-like structures appear to form without involvement of defined extrinsic ligands and rely on stochastic binding to bacterial surface proteins to initiate self-assembly.
All B. thuringiensis crystal proteins (Cry proteins) which are toxic to target insects share general traits in their mode of action: solubilization in the midgut, activation by gut proteases, binding to membrane surface proteins (generally referred to as 'receptors') [ 6, 7].
Since our screen was performed using a library selected for binding to HT1080 surface proteins, and thus might have a tendency to target proteins upregulated in these cells, we profiled CD155 expression in these and other cells.
ODN-dendrimer uptake was energy-dependent and mediated, at least in part, via binding to cell surface proteins; a process that was inhibited by self-competition and by competition with free ODN, salmon sperm DNA, heparin and dextran sulphate.
Upon binding to viral surface proteins, the antibodies block the virus-receptor interaction and inhibit virus infection.
The authors of this study propose a model whereby HD6 binding to bacterial surface proteins, such as flagella, triggers the assembly of nanonets that contain the microbes.
Such bispecific adaptors or bridge complexes can take different forms, for example, two different antibodies, modified with biotin, can be linked via avidin or streptavidin thus ensuring specific binding to viral surface proteins and the target molecule on the cell at the same time [ 20].
The binding of leptospiral surface proteins to PLG was specific, dose-dependent and saturable.
