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It modulates cellular interaction with the ECM by its binding to structural matrix proteins, such as collagen and vitronectin, and by its abrogation of focal adhesions, which are features contributing to a counter-adhesive effect on cells.
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By binding to structural proteins such as collagen type I, SPARC regulates cellular interactions with the extracellular matrix [ 21].
Within the dermis, ECM1 has a role in the structural organization of the dermis, binding to perlecan, matrix metalloproteinase-9, and fibulin.
The HA0 decrease is associated to both structural matrix integrity and biochemical content.
Furthermore, as in EO, matrix receptors binding to the structural components of the ECM have an impact on chondrocyte behavior in articular cartilage.
These adhesins facilitate binding to various matrix proteins or host cells [29].
This greatly reduced the binding of native E. coli proteins binding to the matrix.
Thus, sasC does not mediate binding to these extracellular matrix proteins or to activated platelets.
Heterogeneous nuclear proteins (hnRNPs) are important nuclear structural proteins and possible constituents of a nuclear matrix, and are thought to organize the genome by binding to putative matrix-associated regions (MARs) in the DNA.
A control selection was performed to control for non-specific binding to the antibody-bead matrix.
The hyaldherin molecules include structural matrix hyaluronic acid-binding proteins as well as cell surface receptors that bind with high affinity to hyaluronic acid [ 74].
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