Sentence examples for binding to specific targets from inspiring English sources

Various in silico techniques like molecular dynamic (MD) simulations, quantum mechanical (QM) calculations, and docking (see [ 2]) primarily detect candidate molecules for general binding to specific targets.

The search properties include nontoxicity, ability to cross the blood brain barrier (that is, low molecular weight lipophilic molecules), rapid clearance from the bloodstream and selective binding to specific targets (that is, tau) in a reversible fashion [ 92].

miRNAs, a group of small non-coding RNAs, regulate gene expression by binding to specific target sites on messenger RNA to either repress or degrade targets.

MiRNAs mediate gene silencing by binding to specific target sites within the 3'UTR of mRNA to either block translation or to bring about degradation of transcripts.

PRDM9 is likely to be important in determining the location of recombination events by binding to specific target motifs in a wide range of animals (Ponting 2011).

MicroRNAs (miRNAs) are short non-coding RNAs that induce silencing and destabilization of messenger RNAs (mRNAs) by binding to specific target sites [ 1, 2].

miRNAs are a class of small noncoding RNA molecules that modulate gene expression by binding to specific target messenger RNAs to prevent their translation and/or to promote degradation.

In this study, we demonstrated short circular TFO RNAs between 28 and 34 mers (Table 1), which are able to inhibit FIPV replication by binding to specific target regions of the FIPV genome.

In these instances of imperfect complementarity, there is often a short, ∼6 8 nt "seed" region, located near the 5′ end of the miRNA, which appears to be of paramount importance in terms of dictating binding to specific target mRNAs [1].

ASSET leads to replacement of some of the critical amino acid residues that affect the biological function in three-finger toxins as well as change the conformation of the loop that is involved in binding to specific target sites.

VDR is heterodimerized with 9- cis-retinoic acid receptor (RXR) and VDR RXR complex modulates gene expression via binding to specific target gene promoter regions, known as vitamin D response elements (VDREs), to activate or suppress their expression [ 35].