Sentence examples for binding to specific target from inspiring English sources

miRNAs, a group of small non-coding RNAs, regulate gene expression by binding to specific target sites on messenger RNA to either repress or degrade targets.

MiRNAs mediate gene silencing by binding to specific target sites within the 3'UTR of mRNA to either block translation or to bring about degradation of transcripts.

MicroRNAs (miRNAs) are short non-coding RNAs that induce silencing and destabilization of messenger RNAs (mRNAs) by binding to specific target sites [ 1, 2].

PRDM9 is likely to be important in determining the location of recombination events by binding to specific target motifs in a wide range of animals (Ponting 2011).

In this study, we demonstrated short circular TFO RNAs between 28 and 34 mers (Table 1), which are able to inhibit FIPV replication by binding to specific target regions of the FIPV genome.

ASSET leads to replacement of some of the critical amino acid residues that affect the biological function in three-finger toxins as well as change the conformation of the loop that is involved in binding to specific target sites.

Various in silico techniques like molecular dynamic (MD) simulations, quantum mechanical (QM) calculations, and docking (see [ 2]) primarily detect candidate molecules for general binding to specific targets.

The search properties include nontoxicity, ability to cross the blood brain barrier (that is, low molecular weight lipophilic molecules), rapid clearance from the bloodstream and selective binding to specific targets (that is, tau) in a reversible fashion [ 92].

One particular important ncRNA class is microRNA (miRNA), single-stranded, 19 25 nucleotide long RNAs that repress translation by binding to specific mRNA target sites.

Modified BMPs with one or more of the following characteristics are being considered: (i) improved binding affinity to specific target cell surface BMP receptors, (ii) decreased sensitivity to natural BMP inhibitors, (iii) better immunogenicity profile, and (iv) increased solubility and stability, to cite a few.

These probes can be designed for high affinity binding to specific molecular targets and be used as tools in the early development of drugs, particularly for neuropsychiatric disorders.