Sentence examples for binding to specific regions from inspiring English sources

ZFN are proteins capable of binding to specific regions of DNA.

By binding to specific regions of DNA sequences, TFs can control the transcription activities of target genes, thus regulating the production of mRNA transcripts [ 7- 9].

HuR binding to specific regions of caspase-2 mRNA was analyzed by crosslinking-RNP-IP assay by using a protocol from Niranjanakumari et al., with slight modifications as described previously.

With the exception of FAS, statistically significant increase in ERα binding to specific regions of the above genes upon E2 treatment was observed in MCF-7p, MCF-7AKT, or both cell types.

As dimers, ERs are able to start transcription activity in two ways: through direct binding to specific regions of DNA, or through protein-protein interaction with other transcription factors.

The CXXC domains are important for TET proteins binding to specific genomic regions for their action (Xu et al., 2012; Tan and Shi, 2012; Jin et al., 2014), and they can cooperate with the catalytic domain to regulate the key gene expression (Xu et al., 2012; Ko et al., 2013).

In this study, we demonstrated short circular TFO RNAs between 28 and 34 mers (Table 1), which are able to inhibit FIPV replication by binding to specific target regions of the FIPV genome.

The role of the upregulation or downregulation of a given miRNA depends on whether it is positively or negatively regulating protein expression at the post-translational level by binding to the 3'untranslated region of its target mRNA [ 3] or acts by another mechanism, such as inducing expression by binding to specific promoter regions in the nucleus [ 6].

Runx2 has an essential role in osteoblastic differentiation of stem cells and directly stimulates transcription of its important downstream target genes, including those encoding osteocalcin (OCN), type I collagen (COL1A1), and osteopontin (OPN), by binding to specific enhancer regions containing the core sequence.

In both cases, reproducible binding was seen to specific regions upstream of the starting codon.

STAT3 is known to regulate the expression of many downstream targets important in tumor growth and survival such as survivin and VEGF through its binding to specific sequences in promoter regions of these target genes.