Sentence examples for binding to specific proteins from inspiring English sources
Chemicals typically initiate their therapeutic and adverse effects by binding to specific proteins through protein ligand interactions.
Among these caspases, caspases 8, 9, and 10 are initiator caspases that are activated through binding to specific proteins, while caspase-3 is an effector caspase that is subsequently activated by the active initiator caspases through proteolytic cleavage.
Most disordered regions interact with protein or DNA, and may acquire ordered structure upon binding to specific proteins, DNA sequences or ligands.
The observed microcystin binding to specific proteins in cells of the natural producer Microcystis could possibly precede dimerization of cysteines and thus detain enzymes from conformational changes or even loss of their catalytic activity.
Several studies have demonstrated that lncRNAs usually perform their molecular functions by binding to specific proteins (Maruyama, 2012).
Extensive studies were thus focused on covalent binding to specific proteins as a trigger of the toxicity.
Upon binding to specific protein partners they form snoRNPs that process rRNAs (by catalyzing pseudouridylation, methylation and cleavage) and contribute to their folding, thereby playing an important role in ribosome biogenesis.
They could function (i) as decoys to locate transcription factors; (ii) as regulatory signals for transcription; (iii) as scaffolds to aggregate different proteins; (iv) as a 'sponge' to interact with microRNAs and (v) as guides to binding to specific protein to target genes.
Previous computational approaches exist that link small molecule binding to specific protein domains, but these approaches use information extracted from crystal structures of protein-ligand complexes to transfer binding annotations between homologous proteins (Davis and Šali, 2010; Finn et al., 2014; Snyder et al., 2006).
