Sentence examples for binding to specific oncogene from inspiring English sources

At last we put forward the some current challenges and solution in developing targeting anticancer drugs binding to specific oncogene.

They operate by binding to specific phosphorylated sites on such diverse target proteins as oncogene products, tumour suppressor proteins, and regulators of cell survival, proliferation and growth [ 52]. 14-3-3s associatedassociated with dynamic nucleo-cytoplasmic shuttling.

Promising alternative approaches include strategies to target specific oncogenes and oncogenic pathways.

Non-specific binding was subtracted from total binding to obtain specific binding.

miRNAs can act as both tumor suppressors (by binding to oncogenes and suppressing them) and oncogenes (by binding to tumor suppressor genes and suppressing them) [ 4].

Tumour regression observed in many conditional mouse models following oncogene inactivation provides the impetus to develop, and a platform to preclinically evaluate, novel therapeutics to inactivate specific oncogenes.

Non-specific binding obtained by incubating 1 mM L- glutamate in the binding assay was subtracted from total binding to yield specific [3H] AMPA- binding.

In all experiments, nonspecific binding was determined and subtracted from total binding to obtain specific binding.

To determine whether specific oncogene expression resulted in distinct tumor types, we characterized livers from the four genotypes.

Epigenetic regulation includes histone modification and DNA methylation, of which CpG island methylation can be gene-specific; in several different cancers, CpG methylation inhibits binding of the transcription machinery, causing silencing of a specific oncogene, which leads to carcinogenesis [11], [12], [13].

Although NFAT is overexpressed in other cancers, activation has never previously been linked to the mutation of a specific oncogene.