Sentence examples for binding to specific nuclear from inspiring English sources
In peripheral tissues thyroid hormone effects are mediated by binding to specific nuclear thyroid receptors, TRα and TRβ.
Thus, no evidence was obtained for either the −164G or the −170G allele binding to specific nuclear protein(s).
Retinoids play an important role in growth arrest and apoptosis via binding to specific nuclear retinoid receptors, such as retinoic acid receptor β (RARβ) [57].
Steroids may exert their action by genomic pathways, involving hormone binding to specific nuclear receptors (NRs) and subsequent modulation of gene transcription after binding to DNA.
Vitamin A metabolite, retinoic acid (RA) transduces its signals by binding to specific nuclear hormone receptors termed retinoic acid receptors (RAR), which include RAR α, β, and γ [ 32].
The classical mechanism of ER action involves estrogen binding to nuclear receptors followed by receptor dimerization and binding to specific response elements known as estrogen response elements located in the promoters of target genes.
The majority of proteins with nuclear function are actively transported based on its binding to specific karyopherin receptors usually by the presence of NLS and NES signals.
Expression of CA-PKCε in human EC led to specific nuclear translocation of Nrf2, and increased binding of Nrf2 in nuclear lysates to an oligo containing an ARE consensus site.
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors, i.e. ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand.
Estrogens are known to play a critical role in the growth of breast cancers and exert their effects by binding to their specific nuclear receptors.
As such, 1,25(OH)2D exerts its effects by binding to a specific nuclear receptor (vitamin D receptor [VDR]), a ligand-dependent transcription factor that recognizes specific DNA sequences known as vitamin D response elements (DeLuca, 2004).
