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Drugs function by binding to specific locations on target molecules and causing a certain desired change, such as disabling the target or causing a conformational change.
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A Kinase Interacting Protein (AKIP1) was identified as a novel PKAc binding protein that targets PKAc to specific locations within cells [11].
The user can limit a search to specific locations (for example, binding region calls from a ChIP experiment) or search the upstream regions of a list of specific genes.
PRDM9 is likely to be important in determining the location of recombination events by binding to specific target motifs in a wide range of animals (Ponting 2011).
The targeting of TFs to specific locations is an informational puzzle, as the number of potential binding sites represented by their generally short sequence binding motifs vastly exceeds the minority used in vivo.
TFs are families of small proteins that regulate gene expression by binding to specific promoter sequences.
Importantly, each of these additional agents binds to specific surface receptors, whose location and binding affinity must be considered when investigating their potential to assist in the regenerative process.
She declined to discuss specific locations.
"We could use nanomaterials to target specific locations in the cancer cell itself," he says.
Select one to three specific locations.
Non-specific binding was subtracted from total binding to obtain specific binding.
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