Sentence examples for binding to specific integrin from inspiring English sources

They function primarily through direct binding to specific integrin receptors and heparan sulfate proteoglycans, thereby triggering signal transduction events that culminate in the regulation of cell adhesion, migration, proliferation, gene expression, differentiation, and survival.

Members of the CCN family share four conserved cysteine-rich modular domains that trigger signal transduction in cell adhesion, migration, proliferation, differentiation, and survival through direct binding to specific integrin receptors and heparan sulfate proteoglycans.

Our work demonstrated that ADAMTS-12 regulates cell-ECM binding to specific ECM substrates and cell attachment facilitated by specific integrin cell adhesion molecules.

For the linkage effect, the cleavage fragments binding to specific receptors suffer affection, including CR1, C3aR, alpha-M/beta-2 integrin, alpha-X/beta-2 intetrin and CD21.

After binding to specific seven transmembrane-domain G-protein-coupled receptors, chemokines regulate integrin-mediated adhesion among other effects [ 2].

The use of synthetic peptide toolkits to probe for receptor-binding specificity indicates that the DDRs bind to specific amino acid consensus sequences on fibrillar collagen that are distinct from integrin-binding motifs [ 10– 10].

The cell uptake was successfully blocked by coincubation with unlabeled bivalent-IA in U-87 MG cells which demonstrated specific binding to cell integrin αvβ3 receptor.

Several tracers for positron emission tomography (PET) and magnetic resonance imaging (MRI) that display highly specific binding to the αVβ3 integrin have been successfully tested in animal models of vascular inflammation [7 9] and in human carotid atherosclerosis [10].

In contrast, in vivo studies did not suggest receptor specific binding to integrin α5 β1-positive tumours, possibly due to severe metabolic degradation.

FN is described as a major regulator of EPC differentiation since it promotes VEGF-induced differentiation of EPCs into ECs via specific binding to integrin α5β [ 44].

Yan et al. fused three copies of the RGD sequence to truncated tissue factor (tTF) to produce the fusion protein (RGD 3/tTF for specific binding to integrin αv β3 in vitro and they demonstrated that the addition of RGD binding motifs to tTF increases the binding ability of RGD/tTF to integrin αv β3 in vitro, thus improving the targeting of angiogenic sites [ 23].