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Different environmental pollutants act as hormone mimics, binding to specific hormone receptors or indirectly interfering with hormone signaling.
Nuclear hormone receptors are ligand-activated transcription factors that modulate gene expression through binding to specific hormone response elements.
Progesterone classically signals by binding to intracellular progesterone receptors (PR), leading to receptor dimerisation and binding to specific hormone response elements located in the promoter region of target genes to regulate transcription through interaction with co-regulatory proteins (Mulac-Jericevic & Conneely 2004, Shao et al. 2006, Gellersen et al. 2009).
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Vitamin A metabolite, retinoic acid (RA) transduces its signals by binding to specific nuclear hormone receptors termed retinoic acid receptors (RAR), which include RAR α, β, and γ [ 32].
Steroids may exert their action by genomic pathways, involving hormone binding to specific nuclear receptors (NRs) and subsequent modulation of gene transcription after binding to DNA.
They recognize target genes by binding to specific DNA recognition sequences, known as hormone response elements.
Hormones act indirectly through binding to specific receptors.
In peripheral tissues thyroid hormone effects are mediated by binding to specific nuclear thyroid receptors, TRα and TRβ.
The glycogenic effects of placental lactogen and growth hormone in ovine fetal liver are mediated through binding to specific fetal ovine placental lactogen receptors.
These steroid hormones exert their effects in normal and transformed mammary epithelial cells by binding to specific receptors, ERα and ERβ, that mediate estrogen signaling by functioning as ligand-dependent transcription factors.
Unlike exogenous rhGH that causes production of the bioactive hormone IGF-1 from the liver, sermorelin simulates the patients own pituitary gland by binding to specific receptors to increase production and secretion of endogenous hGH.
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