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Cytokines are small soluble glycoproteins that act in an autocrine or paracrine manner by binding to specific cellular receptors, operating in networks, and orchestrating the immune system's development and function.
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In addition to E2F transcription factors, Rb has also been shown to bind to over 100 additional cellular proteins (Morris and Dyson, 2001), leaving open the potential for differential binding preferences of mono-phosphorylated Rb to specific cellular targets.
In this view, the original role of MvCsk and CoCsk would have been similar to those of other pseudokinases (scaffolding, activating other proteins through domain binding, or targeting of active proteins to specific cellular locations).
LPA transduces its multiple cellular effects via binding to specific LPA-receptors, which belong to the large superfamily of G-protein-coupled receptors (GPCRs).
All members of the TGF β superfamily exert their cellular effects via binding to specific type I and II serine/threonine receptors.
The VCP dislocase serves as the "motor" that mediates those cellular functions by binding to specific cofactors including Ufd1, Npl4, and p47.
It is believed that VCP is directed to relevant cellular processes through differential binding to specific adaptor proteins.
It has been suggested that imatinib inhibits ligand binding to specific receptors on the surfaces of human melanocytes, reducing cellular activity and thus commonly triggering hypopigmentation [10].
TFs play a vital role in regulating gene expression by binding to specific DNA sequences and are involved in many key cellular processes.
Tax transactivates specific cellular transcripts by interacting with DNA-binding serum responsive factor, which recruits Tax to specific cellular promoters such as those of c-FOS, EGR-1 and EGR-2.
Src activity is inhibited by the binding of RACK1 but RACK1 can transport Src to specific cellular compartments where Src can function.
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