Sentence examples for binding to specific E-boxes from inspiring English sources

This requires binding to specific E-boxes throughout the genome, followed by recruitment of chromatin modifying complexes and transcription machinery.

Snail proteins bind to specific E-box sequences in promoters or introns and regulate gene expression.

Snail1 can bind to specific E-box regions on the CDH1 promotor, thus leading to transcriptional repression of E-cadherin.

The most thoroughly studied and understood function of Myc is its ability to activate genes via binding to specific DNA sequences called E-boxes with its partner protein, Max [ 14- 16].

In particular, EMT regulators Snail1/2 and ZEB1/2 are able to repress E-cadherin expression through interaction with specific E-boxes of the E-Cadherin promoter [ 35, 36].

On the other hand, upon binding to two DNA E-boxes, the protein also appeared to be highly disordered.

E-proteins activate transcription by binding to promoter E-boxes.

Most recently, Snail was described to contribute to repress transcription of E-cad gene by binding to the E-boxes of the CDH1 promoter (Giroldi et al, 1997).

These repressors, bearing fanciful names like Snail, Slug, Sip-1, and Twist, exert their effects by binding to different E-boxes in the E-cadherin promoter [ 12].

Snail and Twist repress E-cadherin through binding to E-boxes in the E-cadherin promoter and induce EMT (Yang and Weinberg, 2008).

DOI: http://dx.doi.org/10.7554/eLife.00426.012 > -wrap-foot> In addition to these overall trends, specific E-box sites also provide further insight into the affinity of CLOCK BMAL1 binding.