Sentence examples for binding to small RNAs from inspiring English sources

In recent years, it was found that nucleus localization of AGO4 could be determined by binding to small RNAs [ 24].

Each AGO protein performs biological functions differently by binding to small RNAs and direct transcriptional regulation or/and post-transcriptional regulation of target genes.

The resolution of Ago-associated small RNAs showed a significant landscape of Ago proteins and their binding to small RNAs [ 18, 19, 21, 48- 50].

The presence of AGO1 in the RNA Pol II (8WG16) pulldown fraction indicates that AGO1 might have an affinity for binding to small RNAs arising from heterochromatin.

Hfq is a small abundant RNA-binding protein that functions as a global posttranscriptional regulator of gene expression by binding to small regulatory RNA molecules (sRNAs) and facilitating their interaction with mRNA molecules [45].

We first assayed the binding of DRB2-FlagHA to small RNA duplexes by IP and subsequent labelling with [5′ P]pCp (cytidine-3′,5′-bis-phosphate), which allows detection of any kind of RNA with free 3′-OH moieties.

Hfq is a RNA chaperon which mediates the binding of small RNAs to the mRNA and assists in post-transcriptional gene regulation in bacteria.

Gene silencing is a multi-layered process, involving the combinatorial actions of histone and DNA modifications, chromatin condensation, DNA binding proteins, small RNAs and the intra-nuclear location of genes and gene clusters.

We believe that we can improve the accuracy of in silico predictions by developing simulations in tandem to look more closely at nonspecific binding of the peptide to other small RNAs and/or unmodified tRNAs or ASLs.

This could act by competing with endogenous mRNAs for miRNA binding (Franco-Zorrilla et al., 2007; Poliseno et al., 2010; Jeck and Sharpless, 2014), providing binding sites for small RNAs that elicit transcriptional silencing (Wierzbicki et al., 2009), or through altering protein activity (Feng et al., 2006), binding or specificity (reviewed in Guttman and Rinn, 2012).

p19's binding specificity and its ability to sequester small RNAs has made it a unique protein-based tool for probing the molecular mechanisms of the highly complex RNA silencing pathway in a variety of systems.