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This is due to its combinatorial nature, favoring the random binding to several molecules.
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Upon exposure, subendothelial collagen immediately binds to several molecules from the blood plasma, triggering repair, coagulation and thrombocyte binding.
Most likely, this is due to the fact that each AgNP is capable of binding to several hMT1A molecules simultaneously and by so cross-linking the hMT1A-modified carboxymethylated dextran hydrogel, consequently requiring more stringent conditions for surface regeneration, e.g. 100 mM NaOH.
Since both endogenous THP (from antigens of interest) or exogenous THP (not encompassed by the sequence of the antigen of interest) are able to elicit T cell help, we decided to engineer promiscuous exogenous THP capable of binding to several HLA-DR molecules, in order to cover an important proportion of the human population.
Promiscuous binding to several protease targets demonstrates the emerging importance of quantitative studies on binding specificity.
This RNA-binding protein binds to several small cytoplasmic RNA molecules, known as Y RNAs, and may stabilize these RNAs, preventing degradation [ 89].
OPN binds to several integrins through two adjacent integrin-binding sites in the centre of the molecule: the RGD sequence and the SVVYGLR (SVAYGLK in bOPN).
In the absence of Δ40p53, DO-7 induced a super-super-shift of p53: DNA complexes consistent with the binding of several molecules of DO-7 to the complex.
The tyrosine residue is located within a YVKM motif and this has been shown to serve as the binding site for several molecules (Fig. 1).
Several approaches have been published that predict peptide binding to MHC molecules utilizing known 3D structures.
We first examined Ndk binding to Rab molecules.
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