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Triptans are migraine-specific drugs binding to serotonergic receptors.
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Additionally, clonazepam promotes brain stem serotonergic descending pain inhibition by binding to the central GABAA receptors located within the brainstem [29].
Moderate to high radioactivity was observed in the dopaminergic and serotonergic receptor-rich brain regions, indicating CLZ binding to multiple receptor types.
One factor to take into account is the small, but not negligible, number of serotonergic neurons, and consequently SERT, in the cerebellum, which was used as a reference region, and consequently, we feel it is unlikely that using the cerebellar binding to assess non-specific binding has significantly influenced our results.
In addition to tiapride binding to the supersensitive D2 dopamine receptors in the ventral striatum and parts of the limbic system (Locus coeruleus), a blockade of some serotonergic receptors (5HT3, 5HT4) is assumed.
Several lines of evidence point to serotonergic abnormalities in patients with panic disorder (PD).
In 44 out of 61 patients (72 %), the use of drugs potentially contributing to serotonergic toxicity was recorded.
In 44 out of 61 patients (72,1 %) the use of drugs potentially contributing to serotonergic toxicity was recorded.
Migraine is the most common neurological disorder linked to serotonergic dysfunction.
ASD is related to serotonergic genes [ 87].
Smoking has been linked to serotonergic dysfunction [ 3].
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