As a transcription factor, many of the functional cellular roles of the p53 protein are elicited through direct DNA binding to sequence-specific cis-regulatory elements [ 3] leading to the transactivation or transrepression of target genes.
Myc is a bHLH-Zip (basic region, helix loop helix, leucine zipper) protein which dimerizes with bHLH-Zip partner proteins like Max upon specific binding to DNA sequence elements termed E-boxes (Eilers and Eisenman, 2008).
In distinction to previous reports on binding sites of other transcription factors within repeats [18], [19], [20], [21], we demonstrate a specific induction of STAT1 binding to selected repetitive sequence elements in reaction to a signal increasing the nuclear concentration of STAT1.
CDP acts as a transcriptional repressor by binding to unique nucleotide sequence elements and is also involved in the regulation of gene transcription through nuclear matrix attachment (22).
The chromatin landscape and promoter architecture are dominated by the interplay of nucleosome and transcription factor (TF) binding to crucial DNA sequence elements.
We also showed that these ATFs activate transcription from GAL1 promoter by binding directly to specific sequence elements in the promoter.
Editing sites are recognized by RNA binding proteins that bind sequence elements immediately upstream of the C-residue to be edited.
Here, we employed ChIP-seq in the context of a controlled fasting/re-feeding experiment — a robust model of CREB activation downstream of the cAMP/PKA pathway — to elucidate the role of CREB binding at specific sequence elements in the regulation of fasting-responsive genes in the liver.
The data therefore suggest significant binding of TBP to proximal TATA and possibly weak binding to initiator elements and sequences within the intron.
The multimeric protein complexes interact with their target promoter sequences [ 2, 3] by binding to cis elements with the canonical sequence CC(A/T6 GG, termed the CArG box [ 10, 13, 14, 16, 19- 21].
