Sentence examples for binding to selected target from inspiring English sources
Lazar and colleagues have previously investigated the interdependence of C/EBPα and PPARγ binding in mature 3T3-L1 andpocytes and failed to see an effect of C/EBPα knockdown on PPARγ binding to selected target sites in mature 3T3-L1 adipocytes [ 16].
Using the recent release of the mirBase database to find potential targets of miRNAs, this model incorporated twelve structural, thermodynamic and positional features of miRNA:mRNA binding sites to select target candidates.
(D ) ChIP-qPCR analysis of Zfp335 binding at selected targets to validate ChIP-seq-based assessment of differential binding in blt / blt thymocytes.
(A ) ChIP-qPCR analysis of Zfp335 binding at selected targets in sorted CD4SP thymocytes.
Docking studies of compounds 6b and 6j were performed against wild HIV-1 RT in order to predict their putative binding mode with selected target.
The ability of CE to select target-binding candidate molecules makes it a potentially powerful tool to discover aptamers and other drug candidates, as can be seen in Fig. 2.
To select targets of peptide inhibitors, we manually examined if predicted targets have peptide-binding domains that have relevance to cancer.
CDDP concentrations that were cytotoxic to UKF-NB-3rNutlin10 μ M cells did neither induce expression of p53 target genes nor binding of p53 to the promoters of selected target genes.
In biotechnological applications, it has been demonstrated in vitro that random association of different ankyrin repeat units can produce engineered ankyrin domains with binding affinity for selected targets [ 40, 41], the same is true for designed LRR- and tetratricopeptide-repeat proteins.
ER-alpha and mutant p53 may also potentially cooperate to transcribe selected target genes by cooperative docking to non-canonical promoter-binding sites (100).
Fifty molecules were designed and included in the in silico analysis to evaluate their druglikeness and binding affinities towards the selected target proteins using various pharmacokinetic and docking software.
