Sentence examples for binding to restore from inspiring English sources

This differential binding to restore individual phenotypes is an example of tissue specificity of protein function and highlights the importance of examining molecular pathways in a tissue-specific manner.

Three AsK132958 analogues, each containing a Tyr in the vicinity of Lys19, were therefore generated in an effort to restore binding, but none showed activity against any of KV channels tested.

However, presence of the negatively charged phosphates destabilized nucleotide association and required Mg2+ ion presence to restore binding affinity.

We find that neuronal overexpression of an Arfip molecule with a mutated GTPase binding domain (GBD) fails to restore synapse growth in arfip mutants compared to the neuronal overexpression of wild type Arfip, which we have found results in neuronal overgrowth (Fig. 3E) (Chang et al., 2013).

Substituting in the Roc1b RING domain, however, was able to restore Cullin binding, and the resulting ANBR protein displayed a Cullin binding profile identical to Roc1a.

Ligands are then appended to the distal end of the steric polymer to restore cell binding and expression at target cells.

We report here the use of multiple stabilizing substitutions to increase the stability of p16INK4a and furthermore, to restore Cdk4 binding activity of several defective, cancer-related mutant proteins.

Sebastian Matthes calls on Chancellor Angela Merkel to restore a binding vision for her country.

The idea was to multimerise recombinant monovalent antibody derivatives (scBsDbs) via suitable linker molecules and, thereby, not only to restore the binding capability of the polyvalent maternal IgM antibodies but also to deliver antigenic peptides to slanDCs.

This covalent modification of the mutant protein is sufficient to restore its binding ability to its transcriptional targets [ 71].

In a third case, intermolecular contact between mitochondrial CYB and nuclear CYT1 encoded components of the cytochrome bc1 complex are likely to restore protein binding.