Furthermore, binding of transcriptional inhibitors to responsive elements in the transgenic construct results in reduced expression of the transgene [19] [21].
Most TCDD effects are mediated by its binding to the aryl hydrocarbon receptor (AhR), leading to AhR nuclear translocation, heterodimerization with aryl hydrocarbon receptor nuclear translocator (ARNT), and binding to xenobiotic responsive elements present in the promoters of target genes (Barouki et al. 2007; Puga et al. 2009).
The biological functions of estrogen are mediated through ER, which regulates transcription of ER target genes by binding to estrogen responsive elements (EREs) [2].
Previous studies have shown that PXR directly activates SREBP1c and CD36 by binding to PXR responsive elements in the CD36 promoter.
In iron-starved cells, both IRPs are activated for binding to iron responsive elements (IREs) within the untranslated regions of several mRNAs and thereby modulate their stability or translation.
Under hypoxic conditions, hydroxylase activities of PHDs are attenuated, resulting in HIF-1α stabilization and eventually the formation of active HIF-1 that regulate gene expression of HIF-1 target genes by binding to hypoxia responsive elements (HREs) [14], [19].
The classical genomic function involves AhR nuclear translocation and binding to xenobiotic responsive elements located in the promoters of target genes, CYP1A1 and CYP1B1 [ 12].
Co-expressed genes in module dark-turquoise were significantly associated with meat quality and based on the current knowledge of gene functions some links among them are suggested to be relevant For example, one member of this module, CREM, is a transcription factor binding to cAMP-responsive elements (CREs) in the promoters of various genes.
Proinflammatory cytokines, such as tumor necrosis factor (TNF -α, may induce insulin resisTNF -αby binding to insulin-responsive elemayts induceletal muscle (10).
