Sentence examples for binding to regulatory elements from inspiring English sources

In addition, ERα, PR, and P300 binding to regulatory elements showed distinct genomic landscapes between MCF-7 and T47D cell lines in the same hormonal states.

SR proteins participate both in constitutive and alternative splicing by recruiting the general splicing machinery to splicing signals and by binding to regulatory elements in the pre-mRNA [14], [17], [18].

SOX9 was found to regulate the expression of COL2A1, ACAN and COL10A1 by specifically binding to regulatory elements in the promoter region of these genes [ 40].

At last, IκBNS drives the development of regulatory T cells by binding to regulatory elements of the Foxp3 locus, whereby IκBNS-deficient mice display reduced Treg numbers [ 80].

Therefore, we investigated the level of PU.1 binding to regulatory elements in known PU.1 target genes (PU.1/Sfpi1, IRF8, and Flt3).

In addition, our ChIP-seq data suggests that SMARCE1 may regulate EGFR expression through direct binding to regulatory elements of EGFR locus.

Nrf2 regulates a battery of protective genes by binding to regulatory antioxidant response elements (AREs).

In the nucleus, Nrf2 activates target genes by binding to regulatory antioxidant response elements (AREs) (45).

Here we demonstrate that once established, the long-range interactions of the active β-globin locus with other active genes are not dependent on the process of ongoing transcription or on the binding of RNAPII to regulatory elements.

These observations demonstrate that the long-range interactions, in cis as well as in trans, of the ubiquitously expressed Rad23a locus with other active genes are also not dependent on the process of ongoing transcription or on the binding of RNAPII to regulatory elements.

Remarkably, we observed a weaker positive LRC region covering the upstream of TSS (~-190 bp to ~-30 bp), suggesting that the dynamic nucleosomes do not occlude the binding of TFs to regulatory elements in vivo.