Such domains might be a direct result of protein binding leading to receptor clustering [28], which, in turn, can modulate the entire membrane organization.
The simultaneous binding of multiple ligands to multiple cellular receptors can lead to receptor clustering.
More questions remain to be answered, such as how reelin binding promotes receptor clustering and if there could be additional receptors for reelin.
DIDS had no effect on either antibody binding to the receptor or receptor-stimulated phosphatidylinositol turnover.
Consequently, it is important to measure the cluster size of adaptor-bound EGFR and to determine whether there is a relationship between adaptor binding and receptor cluster size.
Second, binding surface receptors by Abs might interfere with ligand binding or receptor clustering.
For example, heterozygous deletion of the γ2 GABAAR (γ2+/−) subunit results in a brain region-specific reduction (6 35%) in [H] flumazenil binding and receptor clustering, with the most pronounced changes occurring in limbic and cortical regions (Crestani et al., 1999).
Syntenin is a scaffolding-PDZ domain-containing protein involved in multiple biologic functions, including syndecan binding and recycling, receptor clustering, protein trafficking, signal transduction, and regulation of the transcription factor Sox4 proteasomal degradation [ 2- 7].
There are multiple observed effects of IA-HA treatment that produce chondroprotection, many of which are results of HA binding to cluster of differentiation 44 (CD44) receptors.
