Sentence examples for binding to platelets from inspiring English sources

Activation of platelets was identified with the use of flow cytometry by the binding to platelets of fluorescein isothiocyanate labeled fibrinogen (that binds to the activated conformer of glycoprotein IIb-IIIa) and phycoerythrin-labeled anti-CD62 that binds to P-selectin on the surface of activated platelets (Becton Dickinson) as previously described (5, 13, 14).

Centocor's Reopro, for instance, prevents blood clots by binding to platelets and preventing the platelets from clumping together.

Ginsberg, M., Pierschbacher, M. D., Ruoslahti, E., Marguerie, G. & Plow, E. Inhibition of fibronectin binding to platelets by proteolytic fragments and synthetic peptides which support fibroblast adhesion.

Using this compound, along with highly selective second-generation inhibitors of AADACL1, metabolomics, and RNA interference, we show that AADACL1 regulates platelet aggregation, thrombus growth, RAP1 and PKC activation, lipid metabolism, and fibrinogen binding to platelets and megakaryocytes.

We actually found that admission levels of fibrinogen binding to platelets of ICU patients were predictive of later sepsis acquisition.

In ischemic stroke, two studies showed increased expression of platelet P-selectin and fibrinogen binding to platelets as compared to controls [25, 29].

The intrinsic fluorescence of the compounds permits their binding to platelet membranes to be readily monitored.

We further assess whether the "cloaking technology" can sufficiently equip nanoparticles with platelet-mimicking functionalities to include in vivo targeting of damaged blood vessels and binding to platelet-adhering opportunistic pathogens.

Although there were no changes in platelet aggregation response and membrane fluidity observed in any of the diets, increased anti-aggregatory prostaglandin E1 binding to platelet membranes was observed only in the case of linoleic acid-rich diet.

The procoagulant action of heparin, which was later characterized as an immunologic reaction by binding to platelet-factor IV, presenting as heparin-induced thrombocytopenia, remains as a side effect.

Inspired by the ternary complex formation of heparin with antithrombin III and thrombin, the active pentasaccharide fondaparinux has been succeeded by several clinical candidates, such as SR123781, that have tailor-made factor Xa and thrombin inhibitory activities combined with less aspecific binding (e.g. binding to platelet factor 4 involved in thrombocytopenia).