Sentence examples for binding to phosphorylated partners from inspiring English sources

The RING domain functions as an E3 ubiquitin ligase by recruiting an E2 ubiquitin-conjugating enzyme, while the BRCT domains are phosphopeptide recognition modules [ 2, 3] that enable BRCA1 binding to phosphorylated partners such as Abraxas, BACH1, and CtIP [ 1].

Similarly, Itk requires binding to phosphorylated SLP-76 to maintain its active conformation [13].

Importantly, this ubiquitination event does not aect Smad4 stability but inhibits its binding to phosphorylated Smad2.

Thus, binding to phosphorylated sequences is a crucial property of Bub3.

Moreover, tumor-associated mutations in the BRCT domains of BRCA1 abolish binding to phosphorylated substrates.

SOCS3 inhibits leptin signaling by binding to phosphorylated tyrosine residue of the leptin receptor (22).

They function primarily by binding to phosphorylated proteins [ 7], although other modes of binding have been reported [ 8– 11].

Many proteins function by binding to multiple partners.

These questions apply to transcription factors binding to genomic DNA and to protein interaction domains binding to their partners.

Specific binding to active phosphorylated receptor was the first arrestin function discovered (Kuhn et al., 1984).

The binding to active phosphorylated GPCRs was long considered the only function of arrestins.