Sentence examples for binding to overexpressed cell from inspiring English sources

Tracers binding to overexpressed cell surface receptors such as PSMA are more favorable since they bind prostate cancer cells independent of proliferation [15 17].

In GTPγS binding assays of overexpressed cell systems (mainly HEK293 cells), GPR55 activation was observed following application of many natural and synthetic cannabinoids as well as following application of endocannabinoids like anandamide but these results were not confirmed in other assays of receptor activation (e.g. β-arrestin activation [ 13]).

These observations reveal greater levels of EGF4KDEL binding to MM cells with overexpressed EGFR and IL-4R compared with normal mesothelial cells.

Multiple studies have previously demonstrated that internalization of affibody molecules by cancer cells after binding to an overexpressed receptor is rather slow, 20 30 % of cell-bound tracer per day (Ahlgren et al. 2008, 2009; Wållberg et al. 2011; Tolmachev et al. 2012a; Orlova et al. 2013).

Cellular targeting can face problems in the way of tissue barriers which vascular targeting avoids by providing nanoparticles with direct access or binding to the overexpressed targets.

First, reciprocal co-immunoprecipitation by SERCA2 demonstrated its binding to the overexpressed TLR9 in cardiomyocytes (Supplementary Fig S1A).

In all the cell lines, the control cells exhibited significant surface roughness compared to SMAR1 overexpressed cells.

One challenge to the use of targeting ligands for directing nanocarriers to overexpressed tumor cell receptors (or other epitopes) is the ability to selectively deliver therapeutic agents to these cells while sparing off-target (healthy) cells [254].

Because we could not easily distinguish endogenous Sec61α from the mutants expressed in HEK293 cells, we measured cotransin binding to recombinant Sec61α/γ overexpressed in Sf21 insect cells, as described in Figure 4. CT7 photo-crosslinking assays revealed specific binding to wild-type Sec61α, but greatly reduced and undetectable binding to the M136T and R66I mutants, respectively.

In agreement with our modeling studies, we observed a significant binding of Ptprg Fc to overexpressed rat Cntn5 and Cntn6 by HEK293 cells, as compared to HEK293 cells with no Cntn expression (Fig. 7A).

One approach for increasing the site specificity of a nanoparticulate carrier is to conjugate it with a ligand which can interact with an overexpressed cell receptor.