Sentence examples for binding to other targets from inspiring English sources

However, most of the reported radiotracers failed to visualize COX-2 in vivo due to multiple challenges including low metabolic stability, insufficient inhibitory potency and specificity for COX-2, and high non-specific binding to other targets.

Thus in DLG5 the PDZ domain may be binding to other targets that do not require the classic GLGF motif for interaction.

Compounds of high ligand efficiency but low molecular weight and low lipophilicity are preferred in that they show fewer liabilities in e.g. unspecific binding to other targets, or in the number of putative metabolic soft spots.

14-3-3 14-3-3 14-3-3 14-3-3gets such as phosphoinositide 4-kinase IIIβ [ 21] or CDC25C [ 22] protects these enzymes from dephosphorylation, presumabindingstorically shielding photherrylatargetsiduesuchom protein phosphasases.

The structural results, combined with the large scale target screening data presented in the following section, suggest that the intimate pocket occupancy is a key contributor to specificity via the exclusion of MW150 binding to other targets in the proteome that either lack, or have less accommodating, proximal pockets.

A further indication that binding takes place within this sequence is given by the finding that the interaction between ALG-2 and Scotin shows several features in common with ALG-2 binding to other target proteins.

Improvements in drug design have historically been centered around structure-based optimization of molecule specificity for a targeted protein, in an effort to reduce unintentional binding to other proteins and off-target effects.

However, the derivatisation techniques are time consuming and can cause unspecific binding of the fluorescent dye to other targets thereby disturbing the detection of S1P.

Nonetheless, the outcomes of this competition for mRNA cross talk will depend on how good a competitor SroC is compared to other targets; this will be additionally influenced by the transcription rate of the gltI operon synthesis, the net SroC levels, and the affinity and binding kinetics of GcvB for SroC as compared to the binding of other GcvB targets.

These could be modified further to express antigens of interest, for example non-binding factor H binding mutants, plus other targets to cover invasive disease caused by Nm strains that do not express fHbp, which has been one of the major vaccine antigens considered over the last few years (Lucidarme et al., 2011).

However, MQ binding to cysteines in other targets, for example, thioredoxin reductase, may contribute as well.