Sentence examples for binding to other partners from inspiring English sources

In addition to the BAG domain, BAG3 contains a WW domain and a proline-rich repeat (PXXP; Figure 1a) that mediate binding to other partners.

Perhaps the open conformation of WASP allows binding to other partners involved in podosome dynamics and/or it may allow further subsequent post-translational modifications of WASP that may promote cleavage by the protease calpain and subsequent dissolution of podosomes.

Like XN73 and mPR130/B α3, it might be involved in regulation of PP2A by competing with the other mPR59 isoforms for binding to other binding partners.

Consequently, this protein is not a regulatory PR72/B" subunit strictu senso [ 7] but-based on its sequence-might compete in binding to other cellular partners of PR130.

Supporting for specificity, PKC phosphorylation of GST-SAP97wt and of the single mutants lacking SH3 phosphosites did not alter the binding to other SAP97 partners, that is A-kinase anchor protein 150 (AKAP150), GluA1 and GluN2A (Supplementary Figures 1C E).

Structurally, SHIP2 is a 155 kDa multidomain protein composed of an SH2 domain that plays a key role in binding to other protein partners, the inositol phosphatase domain, a phosphotyrosine binding site (PTB) in a NPXY consensus sequence, proline-rich sequences, a sterile α-motif (SAM), and recently identified ubiquitin binding domain and phosphorylation sites at Ser132, Thr1254, and Ser1258.

Thus, the NLS domain is likely to play a role in recruiting P1 to the nuclear/ER membrane, where upon binding to other local interaction partners, it forms a recruitment platform for IFs.

The requirement of two independent motifs for the optimal binding of Vav proteins to other partners is not unprecedented.

Previous studies have shown ERα regulates its target genes through three major binding models a) direct binding to ERE (estrogen response element); b) indirect binding, through which it binds to other TF partners which bind to DNA; and c) co-occurrent binding, where both ERα and other TF partners bind to their own specific DNA motifs (Additional file 3, Figure S2) [ 20- 22, 40, 41].

Proteins often perform their functions through physically binding with other partners.

In many cases, when a protein adopts an "auto-inhibited" conformation, its active site for substrates, or binding sites for other partners may be blocked and thus this state is also referred to as an "inactive" state; while, in an "active" state, the autoinhibitory conformation is released, making the active or binding sites available for interaction with substrates or regulatory partners.